Cyclooxygenase activity/inhibition curcumin

Park C, Kim GY, Kim GD, Choi BT, Park YM, Choi YH. 2006. Induction of G2/M arrest and inhibition of cyclooxygenase-2 activity by curcumin in human bladder cancer T24 cells. Oncol Rep 15 1225-1231. 

Plummer, S.M., Holloway, K.A., Manson, M.M., Munks, R.J., Kaptein, A., Farrow, S., and Howells, L., Inhibition of cyclooxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signaling complex. Oncogene, 18, 6013, 1999. 

Cyclovalone (25), which differs from curcumin in the linker between the two phenyl rings, and three analogs showed anti-inflammatory activity based on inhibition of the enzyme cyclooxygenase [14], Fig. (5). Curcumin was used as a reference, and compounds 26, 27, and 28 were more potent than curcumin. Compounds 26 and 28 showed greater inhibition than compounds 25 and 27, respectively. Therefore, in this series, di-methyl substitution enhanced the ability to inhibit cyclooxygenase more than mono-methoxy substitution. Compound 25 showed greater inhibitory activity than compound 27 however compounds 26 and 28 had similar activity. Hence, the authors concluded that modification of the cyclic ketone from cyclohexanone to... 

Chun, K.S. et al., Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-kappaB activation. Carcinogenesis, 24 (9), 1515, 2003. 

Lee, K.W., Kim, J.H., Lee, H.J., Surh, Y.J. 2005. Curcumin inhibits phorbol ester induced up-regulation of cyclooxygenase-2 and matrix metalloproteinase-9 by blocking ERKl/2 phosphorylation and NF-kB transcriptional activity in MCFIOA human breast epithelial cells. Antioxidants and redox signaling., 7 1612-1620. 

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