Cyclohexylamine hydrochloride, reaction

Cyclohexylurea has been prepared by the reaction of cyclo-hexyl isocyanate with gaseous ammonia or ammonium hydroxide, by thermal decomposition of cyclohexyl allophanamide, by treating cyclohexylamine hydrochloride with an aqueous solution of potassium cyanate," by heating nitrosomethylurea with cyclohexylamine, and by heating an ethanolic solution of cyclohexylamine and 3,5-dimethyl-l-carbamylpyrazole. 2,6-DimethyIphenyIthiourea has been synthesized by allowing 2,6-dimethylaniline hydrochloride to react with ammonium thiocyanate. ... 

Compound 123 affords on treatment with P20j/N,/V-dimethyl-cyclohexylamine hydrochloride the pyrazolo[3,4-(i]pyrimidines 129. It is also possible to isolate 130 when using o-toluidene hydrochloride. Reaction of 123 with formamide affords the oxopyrazolo[3,4-d]pyrimidine 131 (76JIC426 77JAP7753854 83JHC1447). 

Certain amines are readily prepared by the reduction of aromatic, aryl aliphatic, and heterocyclic amines. For example, aniline is reduced to cyclohexylamine by high-pressure hydrogenation in the presence of Raney nickel catalyst or a cobalt oxide-calcium oxide catalyst. The reaction occurs at a temperature above 200°, where condensation of the primary amine also takes place, viz., 2CjHiiNHj — (CjHn),NH + NH,. If this side reaction is repressed by the presence of dicyclohexylamine at the start of the reaction, a 94% yield of cyclohexylamine is obtained. Hydrogenation of aryl aliphatic amines proceeds more readily, occurring at moderate temperatures and pressures over platinum catalyst in glacial acetic acid. Other reductions using this catalyst are best performed on the amines in the form of their hydrochlorides. ... 

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