Cyclohexyl morpholine

Trichloroacetic acid [1, 1194, before references]. Trichloroacetic acid reacts with the cyclic enamine 1-morpholino-l -cyclohexene in ethylene dichloride with elimination of carbon dioxide and formation of N-[l-(trichloromethyl)cyclohexyl]morpholine,... 

Figure 7. CIDS key search for cyclohexyl morpholine compounds...

A reversion of the addition direction has been observed in the case of electron rich alkenes such as enol ethers and enamines. For example, ethyl vinyl ether reacts with the mesoionic compound (9) to produce the cycloadduct (108) in 58% yield. Other examples are the reactions of mesoionic 1,3-dithiolones with cyclohexyl vinyl ether, cyclopenten-l-yl ethyl ether, ethyl isobuten-l-yl ether and /V-(isobuten-l-yl)morpholine. The observed regioselectivities have been also qualitatively discussed on the basis of MO perturbation theory (79LA360). 

Isocyanat 1,1-Dipropyl-butyl- E4, 763 (R-CO-NH-C1 4- Amin) Morpholin 2-Cyclohexyl-3-methyl-VI/4, 542... 

Hexensaure 2,3-Dimethyl- -diethylamid E21d, 3410 (3-OH-en + l-NR,-in) Morpholin 4-Cyclohexyl-2,6-... 

Preparation from cyclohexyl isothiocyanate and N-(2-aniinoethyl)morpholine (Carbide and Carbon Chemicals Co.). ... 

In acidic solutions, organic amines protonate to form cations with hydrophobic tails. These ions will seek out and blanket cathodic surfaces, much as carboxylate anions seek out and cover anodic spots in neutral or basic media. The usual choices include amylamine (C5H11NH2), cyclohexyl-amine (C6H11NH2), pyridine (C5H5N), and morpholine [0(CH2CH2)2NH]. Metallic iron behaves as a soft acid in terms of the HSAB classification (Section 2.9), despite the indubitable hard behavior of its trivaJent ion, and so molecules with soft donor atoms adsorb more strongly than hard bases (S > N > 0). This principle can be applied to the design of inhibitors. 

The alkylation reaction in a two-phase system was also extended to various heteronucleophiles [11]. Secondary amines (morpholine, benzyhnethylamine, etc.) as well as primary amines (n-butylamine, 2,2-diethylpropargylamine, cyclohexyl-amine, a-methylbenzylamine, etc.) react for example with ( )-cinnamyl acetate to give only the monoaUylated product in quite good yields [Eq. (2)]. The water-soluble nucleophiles sodium azide and sodium p-toluene sulfinate react also under these conditions, giving the corresponding aUyl azide and allyl p-toluene sulfone in 92 and 95% yield, respectively. 

N-Cyclohexyl-2-benzothiazolesulfenamide 1,3-Dibutylthiourea Dicyclohexylbenzothiazyl-2-sulfenamide Dimethyl diphenyl thiuram disulfide 2,6-Dimethylmorpholine Diphenylamine 4,4 -Dithiodimorpholine 2-Ethylbutyraldehyde Ethyl morpholine Formaldehyde aniline 2,6-Lutidine N-Nitrosodimethylamine Paraldehyde p-Quinone dioxime Selenium Selenium dimethyidithiocarbamate Sodium diethyidithiocarbamate Sodium dimethyidithiocarbamate Sodium nitrite N,N,N, N -Tetrabenzylthiuram disulfide Tetraisobutylthiuram disulfide Tetramethylthiuram disulfide Thiocarbamyl sulfenamide Thiophenol Thiourea Triethanolamine Triethylamine Triethylenetetramine n-Valeraldehyde Zinc dialkyl dithiophosphate Zinc diamyidithiocarbamate Zinc dibenzyl dithiocarbamate Zinc diisobutyidithiocarbamate Zinc isopropyl xanthate Zinc 2-mercaptobenzothiazole Zinc oxide Zinc-N-pentamethylene dithiocarbamate Zinc peroxide accelerator, rubber articles for repeated use food-contact... 

Amines, prim., Alkylamines Methyl-, Ethyl-, Propyl-, Butyl-, Cyclohexyl-, Benzyl-amine Hexamethylenediamine Dimethyl-, Diethyl-, Diisopropyl-, Dibutyl-, Dicyclohexyl-amine, Morpholine... 

An example of a CIDS key search is given in Figure 7, where a search is shown for all cyclohexyl (SCN49) morpholine (SCN35) compounds in the NIOSH RTECS data base of acute toxicity. There are only two such compounds in the data base, and the first of these is printed out in the figure, along with its local NIOSH RTECS identifier numbers indicated. 

---