Cyclohexanes pentasubstituted

From the correspondingly substituted A -pyrazolines (18), 1-alkoxy- and l-acetoxy-l,2,2,3,3-pentasubstituted cyclopropanes were obtained in good yields by thermolysis in cyclohexane solution under nitrogen using a high-pressure vessel (91JHC1773). 

Dinitroalkanes (33) were recently used in combination with unsaturated aldehydes (62) for the organocatalytic synthesis of pentasubstituted cyclohexanes (63) by an asymmetric domino Michael/Henry process, which is shown in Figure 2.21 (Reyes et al., 2007). 

Reyes, E.R., Jiang, H., Milelli, A., Eisner, R, Hazell, R.G., and Jpegensen, K.A. 2007. How to make five continuous stereocenters in one reaction Asymmetric organocatalytic synthesis of pentasubstituted cyclohexanes. Angew. Chem. Int. Ed., 46 9202-05. 

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