Cyclododecane- 1-carboxylate

Similar rearrangements have been achieved with vinyl alcohols 12 or 14, respectively949. The structure of the Cope product 15 has been verified by degradation to the known cyclododecane-carboxylic acid (derived from 17). 

A similar procedure has been developed by Chemische Werke Hulls for the oxidation of cyclododecane to a cyclododecanol-one mixture by air in the presence of boric acid with trace amounts of cobalt(II) carboxylate at 160-180 °C and 1-3 atm.556 The ol-one mixture (5 1) is... 

The Bashkirov oxidation (liquid-phase oxidation of n-alkanes or cycloalkanes in the presence of boric acid and hydrolysis) yields the corresponding secondary alcohols [16, 17]. The reaction is used industrially for oxidation of C10 to C18 n-alkanes, providing raw materials for detergents and for oxidation of cyclododecane to cyclo-dodecanol as an intermediate for the production of Nylon 12 (Table 1, entry 8). The process is not of much commercial importance in the western world, however. Oxidation in the absence of boric acids usually leads to mixtures of alcohols, ketones, and carboxylic acids (Table 1, entry 9). 

Study was (N-2 (carboxyethyl)-2-(3 -nitro-l -triazolyl)acetamide, the carboxylic acid derivative of sanazole, which possesses an optimal combination of desired properties such as selective toxicity for hypoxic cells and lowered lipophilicity, resulting in lowered neurotoxicity. The BFCA used was l,4,7,10-tetraaza-l-(4 -aminobenzylacetamido)-cyclododecane-4,7,10-triacetic acid (p-amino-DOTA-anilide), a DOTA derivative. Radiolabelling of the sanazole-BFCA conjugate (Fig. 8.18) with Lu was achieved under optimized conditions, yielding complexation of approximately 98%. 

Decarboxylation of P-keto-esters is facile in aqueous DMSO, but in less reactive cases decarboxylation is accelerated by sodium chloride. Condensation reactions of dibenzocycloheptadienone (334) with aromatic aldehydes have been reported. Syntheses of the heterocyclic carboxylic acids (335) have been described. No effect of the heterocycle s ring current on the chemical shifts of the methylene protons could be detected in the n.m.r. spectrum of the nonamethylene-thiadiazine dioxide (336), which was prepared from cyclododecane-l,3-dione. ... 

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