Cyclodextrins NOESY

Yamamoto and coworkers used two-dimensional, nuclear Over-hauser effect experiments (NOESY) to determine the proximity of particular protons situated on an included p-nitrophenolate ion to particular protons of a host alpha cyclodextrin molecule. The experiments showed cross-peaks connecting the H-3 resonance of alpha cyclodextrin to both meta and ortho proton resonances of the p-nitrophenolate ion, whereas H-5 of the alpha cyclodextrin gave a cross-peak only with the resonance of the meta proton thereof. As a consequence, it was unequivocally confirmed that the p-nitrophenolate ion is, in solution, preferentially included with its nitro group oriented to the narrow end of the alpha cyclodextrin... 

Crini et al. used HRMAS NMR spectroscopy for exploring inclusion complexes of P-cyclodextrin with textile dye [28]. The authors performed a series of 2D solid-state experiments (NOESY, TOCSY and HSQC) to estabhsh the structure of the IC under investigation. An important contribution was achieved through the HOHAHA experiment. The results showed that, through this new NMR technique, it is possible to characterize cross-linked materials with limited mobility. 

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