Cyclodextrins applications

The formation of complexes of the fluorescent tracer dye ammonium 1-phenyl-aminonaphthalene-8-sulphonate (10.41) with cyclodextrins has been investigated with favourable results, especially in environmental studies [33]. The ability of this dye to complex with cyclodextrins has been exploited mainly as an analytical tool in the study of cyclodextrin applications, since its fluorescence is easily measured. The interaction of a-, P-and y-cyclodextrins with azo acid dyes containing alkyl chains of different lengths has been reported [36,37]. The formation and isolation of solid complexes between P-cyclodextrin and Cl Acid Red 42, Cl Acid Blue 40 or Erionyl Bordeaux 5BLF (Ciba) have been reported [29]. 

Y Martin-Biosca, C Garcia-Ruiz, ML Marina. Fast enantiomeric separation of uniconazole and diconazole by electrokinetic chromatography using an anionic cyclodextrin. Application to the determination of analyte-selector apparent binding constants for enantiomers. Electrophoresis 21 3240—3248, 2000. 

Dubes, A., Degobert, G., Fessi, H., and Parrot-Lopez, H. (2003), Synthesis and characterisation of sulfated amphiphihc alpha-, beta- and gamma-cyclodextrins Application to the complexation of acyclovir, Carbohydr. Res., 338,2185-2193. 

Shimpi S, Chauhan B, and Shimpi P. Cyclodextrins Application in Different Routes of Drug Administration. Acta Pharm 2005 55(2) 139-156. 

Higashi, T., Hirayama, R, Arima, H., Uekama, K. Polypseudorotaxanes of pegylated insulin with cyclodextrins application to sustained release system. Bioorg. Med. Chem. Lett. 2007,17, 1871-1874. 

Gomez-Gomar A., Ortega E., Calvet C., Andaluz B., Merc R., Frigola J., Enantioseparation of basic pharmaceutical compounds by capillary electrophoresis using sulfated cyclodextrins Application to E-6006, a novel antidepressant. J. Chromatogr. A, 990, 91-98 (2003). 

Carcerands and Hemicarcerands, p. 189 Concave Reagents, p. i /1 Crown Ethers, p. 326 Cryptophanes, p. 340 Cyclodextrins, p. 398 Cyclodextrins, Applications, p. 405 Cyclophanes Definition and Scope, p. 414 Enzyme Mimics, p. 546 Macrocycle Synthesis, p. 830 Organometallic Anion Receptors, p. 1006 Soft and Smart Materials, p. 1302 X-Ray Crystallography, p. 1586... 

The absolute majority of all practical applications of CDs (see Cyclodextrins Applications) is based on their inclusion complex-forming capacity. 

Cyclodextrins, p. 398 Cyclodextrins Applications, p. 405 Mesoporous Silica and Silica—Organic Hybrids, p. 852 Micelles and Vesicles, p. 861... 

Classification and Nomenclature of Supramolecular Compounds, p. 261 Crown Ethers, p. 326 Cryptands, p. 334 Cyclodextrins, p. 398 Cyclodextrins, Applications, p. 405 Dendrimers, p. 432... 

This paper scrutinizes the limits of cyclodextrin application in orally administered drug preparations. 

This field is very broad because a vast number of drugs can be complexed. Nevertheless also this field has its definite limits, over which only a negligible rate of succes on account of technical, or economical reasons can be expected. The knowledge accumulated so far on this field allows us to delineate the sensible limits of cyclodextrin applications in drug complexation. Taking these... 

S. Shimpi, B. Chauhan, and P. Shimpi, Cyclodextrins Application in different routes of drug administration, Acta Pharm. Zagreb Croat, 55 (2), 139-156, 2005. 

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