Cyclodepsipeptides, insecticidal

A Suzuki, M Kanaoka, A Isogai, S Murakoshi, M Ichinoe, S Tamura. Bassianolide, a new insecticidal cyclodepsipeptide from Beauveria bassiana and Verticillium lecanii. Tetrahedron Lett 25 2167-2170, 1977. 

Deffieux G, Merlet D, Baute R, Bourgeois G, Baute M-A, Neveu A. New insecticidal cyclodepsipeptides from the fungus Isariafelina. II. Structure elucidation of isariins B, C and D. J Antibiot 34 1266-1270, 1981. 

Bassianolide (61), a further insecticidal cyclodepsipeptide has been isolated from two entomopathogenic fungi, Bauveriana bassiam and Verticillium lecanii by Kanaoka et al. (1977, 1978)... 

Destruxins and bassianolide have no importance in practical plant protection because their recovery is cumbersome, they are highly toxic to warm-blooded animals and, moreover, they are not contact poisons. Their activity as a stomach poison is greatly limited by their antifeedant effect. They are primarily products of theoretical interest, and it is to be hoped that study of them will clarify relationships concerning the mechanism of the insecticidal and antifeedant effects, and will help elucidate the biological effect of cyclodepsipeptide antibiotics of similar structure. 

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