Cyclobutanone O-benzoyloximes

Cyclobutylidene derivatives have been regio- and stereoselec-tively reduced to substituted vinyl cyclobutanes with Pd(dba)2 and sodium formate. Heteroaryl benzylic acetates (including 2° acetates) undergo Pd-catalyzed benzylic nucleophilic substitution with malonate nucleophiles. Cyclobutanone O-benzoyloximes have been converted to a variety of nitrile derivatives using Pd(dba)2 in combination with chelating phosphines (eq 27). ... 

Scheme 3.38 Pd(0)-catalyzed ring contraction of cyclobutanone O-benzoyloxime 66.

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See also in sourсe #XX -- [ ]

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