Acids cycloalkanoic

In addition, we were able to extend the tandem hetero Michael addition/a-ester-enolate alkylation protocol by an intramolecular variant via a Michael-initiated ring closure (MIRC) reaction leading to diastereo- and enantiomerically pure trans-configured 2-amino-cycloalkanoic acids 30 (Scheme 1.1.7) [14c,d]. 

Oxidation of enamines.1 Oxidation of enamines of cyclic ketones in the presence of BFj etherate results in a Favorski type rearrangement to esters of contracted cycloalkanoic acids. A related reaction also occurs with enamines of aryl methyl ketones. 

Cyanuric chloride, 114-115 Cyanuric fluoride, 115 Cyclic carbonates, 274 Cyclic hodroboration, 397-398 Cyclo-(L-Ala-L-Ala), 151 1,3-Cycloalkanediones, 460 Cycloalkanoic acids, 229 Cycloaromatization, 257-258 Cyclobutylidenacetic esters, 9 Cyclocarbonylation, 174-175 1,6-Cyclododccadicnc, 311 Cyclododecanone, 173... 

Lactonization. Unsaturated cycloalkanoic acids are converted by treatment with CeHsSCl into phenylsulfenyl lactones, which arc useful intermediates to a number of products. ... 

Ring contractions. This azide can function in 1,3-dipolar cycloaddition to enamines of cyclic ketones (1). The resulting AMriazolines (a) have not been isolated since they undergo loss of nitrogen with ring contraction to form the ring-contracted products (2). These can be converted into cycloalkanoic acids (3). ... 

The above stabilization effect is limited to systems such as 4 and 5 (Scheme 4), containing at least one functional group (e.g. OH, OR) which undergoes ready dissociation upon CL Other systems, e.g. diesters, with functional groups that are stable under Cl conditions, behave in a different manner. Proto-nated esters of alkanoic or cycloalkanoic acids exhibit a high degree of stability upon isobutane-CI. Protonation occurs at the carbonylic oxygen atom. 

Formation of AllylEsters. AEyl esters are formed by reaction of aEyl chloride with sodium salts of appropriate acids under conditions of controEed pH. Esters of the lower alkanoic, alkenoic, alkanedioic, cycloalkanoic, benzenecarboxyEc, alkylbenzene carboxyEc, and aromatic dicarboxyEc acids maybe prepared in this manner (25). More information can be found about the reactivity of aEyl compounds (see Allyl alcohol and mono allyl derivatives). 

Cycloalkano-2-pyridones (XlI-463) are formed from 2-(2-cyanoethyl)cyclo-alkanones by cyclization to XII-462 with cold concentrated sulfuric acid, which is reduced to sulfur dioxide in a subsequent aromatization. ... 

Curtius reaction, conversion of a pyridine hydrazide to a pyridine amide, 362 Cyanoacetamide, 602, 620 Cyanoacetic acid, 601 Cycloalkano-2-pyridones, preparation from 2- (2-cymo-ethyl) cycloalkanones, 729 a-Cyano-2-butenolc acids, 601... 

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