Cyclo-hexanecarboxylic acid

As further examples, compounds 10 and 11 are both keto acids and mus be named as acids, but the parent name in 10 is that of a ring system (cyclo hexanecarboxylic acid) and the parent name in 11 is that of an open chair (propanoic acid). The full names are frrt/ s-2-(3-oxopropyl)cyclohexane carboxylic acid (10) and 3-(2-oxocyclohexyl)propanoic acid (11). 

Dimethylamine, reaction with cyclo-hexanecarboxylic acid chloride, 39, 20... 

Reaction of the hydrocarbons in this series with phenols or phenol ethers in the presence of suitable catalysts is well known, a-fenchene and phenol yielding a mixture of o- and p-isofenchylphenols in the presence of aluminium phen-oxide practically the same reaction was described seven years ago. Reaction of camphene with a phenol ester in the presence of stannic chloride is reported to give a bornyl compound, but terpenoid rearrangements are notorious under such conditions, and it is doubtful whether this is the only product. 3,3-Dibromocamphor (261) has been converted into substituted cyclo-hexanecarboxylic acids by the route shown in Scheme 13. ... 

Direct C-H activation of hydrocarbon by means of transition metals has also been explored. Cyclohexane reacted with Pd(OAc)2 in the presence of potassium persulfate-trifluoroacetic acid under CO pressure and produced the desired cyclo-hexanecarboxylic acid in low yields and TON (eq. (13)). The electrophilic carbox-ylation is explained by the change of Pd(OAc)2 to Pd(OCOCp3)2 in trifluoroacetic acid as solvent. Electrophilic attack on a C-H bond should give an alkyl Pd complex. CO insertion followed by reductive elimination affords a reactive mixed anhydride which was detected before workup. 

Muro F, Iimura S, Sugimoto Y et al (2009) Discovery of trans-4-[l-[[2,5-dichloro-4-(l-methyl-3-indolylcarboxamide)phenyl]acetyl]-(4 S)-methoxy-(2 S)-pyrrolidinylmethoxy] cyclo-hexanecarboxylic acid an orally active, selective very late antigen-4 antagonist. J Med Chem 52 7974-7992... 

Nylon 6. Poly[imino(l-oxo-l, 6-hexanediyl)] poty(imlnocarboaylpeMamethytene) Caprolan Enkalon Grilon Kapron Mirton Perlon Phrilon Ami Ian. Linear polymer obtained by polymerization of e-caprolactam, q.v. Schlack, US. pat. 2,241,321 (1941 to I. G. Farbenind.). The importance of this fiber increased with the discovery that caprolactam can be produced by the nitrosation of cyclo-hexanecarboxylic acid Muench et al, U.S. pats. 3,022,291 and 3,108,896 (1962, 1963, both to Snia Viscosa). Review R. W- Moncrieff, Man-Made Fibres (John Wiley Sc Sons, New York, 1963) pp 335-355 H. K. Reimschuessel, J. Polym. Sci, Macromol Rev. 12, 65-139 (1977). 

Phenyl- -alanine, cyclohexanone, and ferf-butyl isocyanide in methanol stirred 72 hrs. at 20° -> l-(2-0x0 -4- phenyl -1- azetidinyl) -1- cyclo-hexanecarboxylic acid ferf-butyl-amide. Y ... 

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