Cyclitols and Benzoquinones

Several new fungal metabolites ( azaphilones , having an affinity for nitrogen nucleophiles) related to the well-known sclerotiorin (7) have been reported in recent years. Studies of the fungus Talaromyces luteus have uncovered luteusins A-E (144-148) (440 443). Luteusins A and B were originally named TL-1 and TL-2, and the stereochemistry of C and D was later revised (443). These metabolites have monoamine oxidase inhibitory properties. The related fungus Talaromyces helicus has furnished helicusins A-D (149-152) (444). 

A new family of azaphilones, the RP-1551s (161-168), is produced by Peni-cillium sp. SPC-21609 and they inhibit the binding of PDGF to its receptor (453). RP-1551-7 is identical to luteusin A (144). RP-1551-1 (161) andRP-1551-6 (166) are diastereomers and are different stereoisomers from luteusins C (146) and D (147). 

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