Cyclic adenosine diphosphate ribose

Kannan MS Modulation of calcium signaling by interleukin-13 in human airway smooth muscle role of CD38/cyclic adenosine diphosphate ribose pathway. Am J Respir Cell Mol 9 Biol 2004 31 36-42. 

Other drugs affect intracellular calcium channels of the endoplasmic or sarcoplasmic reticulum, e.g. inositol triphosphate receptor channels open in response to InsPs itself and certain other inositol phosphates, are sensitized by thiomersal (which increases the sensitivity of the receptor to InsPs by acting as a sulphydryl reagent) and antagonized by heparin. The various ryanodine receptor channels, at which a putative natural agonist is cyclic adenosine diphosphate ribose (cADP-R), are activated by caffeine and low concentrations of ryanodine (but antagonized by high concentrations of ryanodine and ruthenium red). 

Nucleoside Cyclic Pyrophosphates. Extensive work has been carried out by Matsuda et al. in their efforts to synthesise chemically stable cyclic adenosine diphosphate ribose (cADPR) analogues. The carbocyclic inosine analogue (83) was first prepared through an efficient cyclisation of an 8-bromo-A-1 -[5"-(phosphoryl)carbocyclic-ribosyl]inosine 5 -phenylthiophos-... 

Cyclic adenosine diphosphate ribose Cyclic AMP-dependent protein kinase... 

Cyclic Adenosine Diphosphate Ribose (cADPR) and Adenosine Diphosphate Ribose (ADPR)... 

G Casabona, L Sturiale, MR L Episcopo, G Raciti, A Fazzio, MG Sarpietro, AA Genazzani, A Cambria, F Nicoletti. HPLC analysis of cyclic adenosine diphosphate ribose and adenosine diphosphate ribose determination of NAD metabolites in hippocampal membranes. Ital J Biochem 44 258-268, 1995. 

Adenosine 2, 5 -bis(phosphate), A-34 Adenosine 3, 5 -bis(phosphate), A-35 Adenosine cyclic 2, 3 -(hydrogen phosphate), A-32 Adenosine cyclic 3, 5 -(hydrogenphosphate), C-162 Adenosine 3 -(dihydrogen phosphate), A-31 Adenosine 2 -(dihydrogen phosphate), A-45 Adenosine diphosphate glucose, A-36 Adenosine diphosphate ribose, A-37 Adenosine diphosphate, A-33 Adenosine 2, 5 -diphosphate, A-34 Adenosine 3, 5 -diphosphate, A-35 Adenosine 2, 5 -diphosphoric acid, A-34 Adenosine 3, 5 -diphosphoric acid, A-35 Adenosine 5 -monophosphate, A-44 Adenosine 5 -(pentahydrogen tetraphosphate), A-38 Adenosine phosphate, A-44 Adenosine 5"-phosphate, A-44 Adenosine 5"-pyrophosphate, A-33 Adenosine 5"-(tetrahydrogen triphosphate), A-39 Adenosine 5"-tetraphosphate, A-38... 

Acetylpyridine adenine dinucleotide, A-23 Adenosine cyclic 2, 3 -(hydrogen phosphate), A-32 Adenosine diphosphate ucose. A-36 Adenosine diphosphate ribose, A-37 Adenosine diphosphate, A-33... 

The nucleotide cyclic AMP (3, 5 -cyclic adenosine monophosphate, cAMP) is a cyclic phosphate ester of particular biochemical significance. It is formed from the triester ATP by the action of the enzyme adenylate cyclase, via nucleophilic attack of the ribose 3 -hydroxyl onto the nearest P=0 group, displacing diphosphate as leaving group. It is subsequently inactivated by hydrolysis to 5 -AMP through the action of a phosphodiesterase enzyme. 

Cyclic adenosine 5 -diphosphate ribose (cADP-ribose), 3-deaza-cADP-ribose, Ryanodine derivatives, BODIPY FL thapsigargin etc. 

Cyclic adenosine 5 diphosphate ribose. This is another second messenger involved with the release of Ca + (11.86c) [25]. 

Figure 7.5 Adenosine diphosphate (ADP)-ribosylation biochemical reactions. Mono-ADP-ribosyltransferases (ARTs) and poly-ADP-ribose pol5mierases Poly (PARPs) catalyse the ADP-ribose moiety of NAD transfer to amino acid residues. ADP-ribosyl cyclases generate cyclic ADP-ribose and 2-phospho-cyclic ADP-ribose from NAD and NADP, respectively. Both molecules trigger cyclic ADP-ribose cytosolic Ca " elevation, presumably by activating the ryanodine receptor in the endoplasmic/sarcoplasmic reticulum (RER). SIRTl catalyses a reaction that couples protein deacetylation to NAD hydrolysis.

There have been further papers related to the second messenger cyclic adenosine 5 -diphosphate ribose (cADPR). Potter s laboratory has reported that the enzyme which cyclizes NAD to cADPR will also produce analogues of cADPR from NAD analogues with modifications in the adenosine unit (2 - or 3 -deoxycompounds, 8-substituents, and the formycin isostere), whilst Sih and co-workers have shown the enzymic cyclization of NADP to cADPR phosphate 3 -NADP and 2, 3 -cyclic NADP also were converted to the cADPR derivatives. The cyclase enzyme has been shown to convert the guanine and hypoxanthine analogues of NAD into products 164 (X=NH2 or H) containing a 7-1" link, as opposed to the 1-1" link in cADPR. The same sort of 7-1" link is formed on enzymic cyclization of l,N -etheno-NAD. ... 

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