Cyclandelate

It has been found that crude cyclandelate may be purified by the following procedure. Crude cyclandelate is dissolved in a solvent chosen for convenience from the class of saturated hydrocarbons. The crude cyclandelate solution is stirred for a suitable interval, typically 1 to 5 hours, with an aqueous solution of sodium borohydride (NaBI-14) at temperatures ranging from 25° to 65°C. The preferred temperature range is 40° to 50°C. The pH of the solution may be adjusted to any desired level in the range between 2.5 to 11.5. The preferred pH range is 8.0 to 11.0 because at lower pH levels borohydride is unstable... 

At the end of the stirring period cyclandelate s recovered by well-known procedures. For instance, the aqueous organic layers may be separated gravimetrically and the product organic layer washed with an appropriate solvent and then distilled, according to U.S. Patent 3,663,597. 

Cyclan Cyclandelate Cyclan-Cap - Cyclandelate Cyclansato - Cyclandelate Cyclapen Cyclacillin Cycleat Cap - Cyclandelate Cyclidox - Doxycycline Cyclobec - Dicyclomine HC ... 

The treatments nsed to improve the brain s oxygen supply include vasodilators, anticoagulants, and raising the oxygen content of the blood. Vasodilators work by dilating arteries. When the arteries supplying the brain are opened wide, the plaques of atherosclerosis are less likely to block blood flow. Vasodilators including papaverine, cyclandelate, isoxsuprine, vincamine, and cinnarizine have all been tried. 

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