Cyclams as Anti-HIV Agents

Tuning the properties of each generation to complement those of particular guest molecules makes it possible to bind those guests and then let them dissociate at a known rate. This controlled release property makes dendrimers potential candidates as drug delivery agents as illustrated in Fig. 7.8 [23], 

Cyclam, 1,4,8,11-tetraazacyclotetradecane, is a cyclic amine readily synthesized from a linear tetraamine precursor, 1,5,8,12-tetraazaduodecane, which is preorganized by a metal template that promotes square planar complex formation, such as nickel, followed by the addition of ethanedione. Reduction of the Schiff base by a 

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