Cyanopyrazines with hydrazine

Reaction of cyanopyrazine and its 6-chloro derivative with hydrazine gives the corresponding amidrazones, these compounds have been prepared for testing as antitubercular agents.262b... 

Cyanopyrazine with dicyanodiamide [(NH2CN)2] gave the 2-(4, 6 -diamino-triazin-2 -yl)pyrazine (63), with o-phenylenediamine in the presence of poly-phosphoric acid at 250 gave 2-(benzimidazol-2 -yl)pyrazine, and with hydrazine gave 2-(C-hydrazino-C-iminomethyl)pyrazine, which condensed with benzil to 2-(5, 6 -diphenyl-as-triazin-3 -yl)pyrazine (64) (1441). 

Although no details have been given, it seems that treatment of the cyanopyrazine 42 with hydrazine in the presence of potassium iodide affords the 3-aminopyrazolo[3,4-h]pyrazine 43. Oxidation of the pyrazoloquinoxaline 44 with aqueous potassium permanganate gave the dicarboxylic acid 45. ... 

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