3- Cyanophenol

Fig. 17. Rate of release of 5-nitro-2-cyanophenolate during decarboxylation of 6-nitrobenzisoxazole-3-carboxylate at 25°C, pH 7.4, p. = 0.05. Initial concentration of substrate, So = 4.18xl0-6M (A) In presence of quaternized polyethylenimine...

In a study of the dissolution of potassium bicarbonate in dimethylformamide (DMF), Compton s group used ultrasound (25 kHz, 8 W cm 2) to provide mixing [18]. The rate was monitored via the homogeneous deprotonation of 2-cyanophenol by the dissolved potassium bicarbonate (Fig. 5.15), using spectroscopic and electrochemical techniques the... 

Fig. 5.15 Reaction of potassium bicarbonate with 2-cyanophenol in DMF to monitor the rate of dissolution of the potassium bicarbonate.

Cyanophenol Sodium hydroxide 2-Nitropropane Nickel Raney... 

A solution of 2-cyanophenol (25.0 g, 0.21 mole), epichlorohydrin (117.0 g, 1.26 mole), and piperidine (10 drops) was stirred and heated at 115-120°C in an oil bath for 2 h. The reaction mixture was then concentrated (90/30 mm) to remove unreacted epichlorohydrin. The residue was diluted with toluene and taken to dryness twice to help remove the last traces of volatile material. The residual oil was dissolved in 263 ml of THF, and the solution stirred at 40-50°C for 1 h with 263 ml of 1 N NaOH. The organic layer was separated and concentrated to give an oil which was combined with the aqueous phase. The mixture was extracted with CH2CI2 and the extract dried (MgS04) and concentrated to give 36.6 g (100%) of 2-[(2,3-epoxy)propoxy]benzonitrile as oil, which slowly crystallized to a waxy solid. 

Epichlorohydrin and 2-cyanophenol are first reacted to give l-(2-cyanophenoxy)-2,3-epoxypropane. 

An attempt to clarify the first stages of the mechanism of carbene formation was undertaken in a nanosecond transient absorption study of 5-chloro-2-hydroxybenzonitrile (4-chloro-2-cyanophenol), based on the hypothesis... 

Treatment of 2-cyanophenol with cysteine in phosphate buffer (pH = 6.4) and MeOH (1 1) at 50°C for 4 days resulted in the formation of the thiazoline in 85% yield <2000T249>. 

FIGURE 2. Common phenols used as photoacids phenol (Ph), 2-cyanophenol (2CPh), 3-cyanophe-nol (3CPh) and 4-cyanophenol (4CPh)... 

While studying the photochemistry of 2-cyanophenol (18), Ferris and Antonucci " reported that the hrst formed product of 18 is isonitrile 19, which then thermally cyclizes to benzoxazole 20 at room temperature ... 

Nitrile [67608-58-6]. 4-Amino-2-hydroxybenzonitrile. 5-Amino-2-cyanophenol C7H N20 M 134.137 Yellow needles (EtOAc/C H ). Mp 182°. 

Amino-2-chlorotoluene, see C-00171 5-Amino-2-cyanophenol, in A-OOl84 2-Amino-5-cyanopyridine, in A-00334... 

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