4- cyano-2-pheny

Reaction of 2-cyanomethylpyridine with iV-(l-aryl-l-chloro-2,2,2-trifluoroethyl)-iV -(4-methylphenyl)carbodiimides, and with (1,1,2,2,2-pentachloro- and l,l-dichloro-2,2,2-trifluoroethyl)isocyanates or A-methoxycarbonyl-l,2,2,2-tetrachloro-, — l-chloro-2,2-trifluoroacetaldehyde imines afforded 3-aryl-4-cyano-l-(4-methylphenyl)imino-3-trifluoromethyl-2,3-dihydro-17/-pyrido[l,2-f]pyrimidines and 4-cyano-3-trichloro-, 4-cyano-3-trifluoro-17/-pyrido[l,2-4pyrimidin-l-ones, respectively <2004CHE47>. Refluxing 2-cyanomethylpyridine and iV-(l-aryl-l-chloro-2,2,2-trifluoroethyl)isocyanates in benzene furnished l-aryl-4-cyano-l-trifluoromethyl-l,2-dihydro-3//-pyrido[l,2-4pyrimidin-3-ones. However, when the solution of the isocyanate was added dropwise to the solution of 2-cyanomethylpyridine, and the reaction mixture was then treated with NEt at room temperature, the isomeric 3-aryl-4-cyano-3-trifluoromethyl-2,3-dihydro-l//-pyr-ido[l,2-dpyrimidin-l-ones were obtained. Reaction of l-(acetyl- and benzoylmethylene)-6,7-dimethoxy-l,2,3,4-tetra-hydroisoquinolines with PhCONCS yielded 1-acetyl-, 1 -benzoyl-9,10-dime thoxy-3-pheny 1-6,7-dihydro-2//-pyrimido[6,l- ]isoquinoline-2-thiones <2003SL2369>. 

Piperidino-4-cyano-4-pheny 1-1,3-butadiene LiC104 in dimethylformamide -0.16... 

I mmol), powdered KOH (0.53 g) and LiClQ, (1.17 g) in PhH (4 ml). The mixture is stirred for I hat60°Candtheoxirane(10mmol) is the added dropwise over 30 min. The mixture is stirred for ca. 8 h, cooled to room temperature, and HzO (10 ml) and PhH (10 ml) are added. The organic phase is separated and evaporated to yield the l-cyano-3-hydroxy-1 -pheny lpropane. 

The preparation of 3,1-benzoxazepines by photochemical isomerization of quinoline A-oxides constitutes a rather general entry into this class of seven-membered heterocycles. Since the structure of the photoisomer of 2-phenylquinoline A-oxide was first recognized as 2-pheny 1-3,1-benzoxazepine by Buchardt et al.,3 the scope of this method for oxidative ring expansion of six-membered heterocyclic A-oxides to 1,3-oxazepines has been extensively explored.4 For example, irradiation of 2-cyano-, 2-phenyl-, and 2-methoxyquinoline A-oxides affords the corresponding 2-substituted 3,1-benzoxazepines in 70-90% yield.5 However, isolation of the moisture-sensitive parent compound was only recently accomplished in the submitters laboratories.6... 

Cyano-1 -pheny lelhanol 2-Cyano-1 -pheny lethanol 2-Trimethylsilyl-l-phenylelhanol... 

Di-tert-butyl 2-cyano-2-pheny 1-2,1 Ib-dihydro-[ 1,3]oxazino[2,3-a isoquinoline-3,4-dicarboxylate (5b) Yellow powder, mp 69-71 °C yield 75%... 

S)-3-methacryloyloxy-1 -(4-azobenzene)pyrrolidine (S)-3-methacryloyloxy-l-(4 -nitro-4- azobenzene)pyrrolidine (S)-3-methacryloyloxy-1 -(4 -cyano-4-azobenzene)pyrrolidine (S)-methacryloyl-3-oxy-N- 4-[(4 cyanophenyl)-(3-carbazoil)-diazenej-pheny 1 pyrrolidine... 

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