6- Cyano-2,3,4,8,9,9«-hexahydropyrido

Neither deuterium incorporation nor double bond migration occurred when 6-cyano-2,3,4,8,9,9n-hexahydropyrido[2,l-Z)][l,3]oxazine (44) was... 

Stereostructure of ethyl c/>4u,7-H-7-phenyl-8-cyano-2-oxo-2,3,4,4u,7,8-hexahydropyrido[l,2-6][l,2]oxazine-8-carboxylate was confirmed by X-ray analyses. It justified a trans ring junction of the bicycle (00OL4007). 

Intramolecular Diels-Alder reactions of azadienes 76 afforded 6-cyano-2,3,4,8,9,9a-hexahydropyrido[2,l-6][l,3]oxazines 77 (99TL7211, 99TL7215). Cyclization was carried out smoothly at or below room temperature in... 

Pyridine-substituted nicotines, nornicotines, and anabasines are available from a-cyano-amines by a new synthesis. The syntheses of ( )-[l - N]nornicotine and ( )-[l - N]nicotine have been described, from cyclopropyl 3-pyridyl ketone and [ N]formamide. 4-Methylnicotine has been prepared it shows no nicotine-like pharmacological activity. " An investigation into the stereochemical factors involved in the behaviour of nicotine and related compounds in the Menschutkin reaction has been conducted.A bridged nicotine , 1,2,3,5,6,10b-hexahydropyrido[2,3-g]indolizine (44), has been synthesized by carboxylation of the dilithium derivative of 2-methylnornicotine followed by cyclisation and reduction with borane in tetrahydrofuran. Several 5-halogeno-nicotines have been prepared and their pK values and biological activities measured. ... 

---