CXCR2 antagonists

Bliss SK, Gavrilescu LC, Alcaraz A, Denkers EY Neutrophil depletion during Toxoplasma gondii infection leads to impaired immunity and lethal systemic pathology. Infect Immun 2001 69 4898. Auten RL, Richardson RM, White JR, Mason SN, Vozzelli MA, Whorton MH Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in hyperoxia-exposed newborn rats. J Pharmacol Exp Ther 2001 299 90. 

White JR, Lee JM, Young PR, et al. Identification of a potent, selective nonpeptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration. J Biol Chem 1998 273 10095-10098. 

Rennard, S. I., Dale, D. C., Donohue, J. F., Kanniess, F., Magnussen, H., Sutherland, E. R., et al. (2015). CXCR2 antagonist MK-7123. A phase 2 proof-of-concept trial for chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine, 191(9), 1001-1011. 

CXCR2 6-OPR Co-IP, (tr)FRFT, BRFT, FC Constitutive CXCR2 antagonist enhances 6-OPR function [77]... 

Low Molecular Weight CXCR2 Antagonists as Promising Therapeutics... 

Researchers at Celltech identified a novel series of nicotinamide N-oxides as CXCR2 antagonist [127]. For instance, 6[Pg.291]

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