Cunninghamella echinulata ATCC

Papavarine H3CO Aspergillus alliaceus NRRL 315 Cunninghamella echinulata ATCC 9244 0 dealkylation [24]... 

Cunninghamella echinulata (ATCC 26269) and Hebmnthosporium spp. (NRRL 4671) are also useful in the benzylic oxidation of ethylbenzenes, both exhibiting enantioselecdvities similar to MortiereUa isa-bellina The en me responsible for these transformations has the diaracterisdcs of a cytochrome P-... 

Nakagawa, K., Miyakoshi, S., Torikata, A., Sato, K., and Tsukamoto, Y. (1991) Microbial conversion of milbemycins Hydroxylation of milbemycin A4 and related compounds by Cunninghamella echinulata ATCC 9244. J. Antibiot. 44,232—240. 

Acronycine 0 0CH3 Cunninghamella echinulata NRRL 3655 Cunninghamella bainieri ATCC 9244 Aromatic hydroxylation [25]... 

Microbial transformations of ellipticine (15) and 9-methoxyellipticine (16) were reported by Chien and Rosazza (143, 144). Of 211 cultures screened for their abilities to transform 9-methoxyellipticine (16), several, including Botrytis alii (NRRL 2502), Cunninghamella echinulata (NRRL 1386), C. echinulata (NRRL 3655), and Penicillium brevi-compactum (ATCC 10418), achieved O-demethylation of 16 in good yield (Scheme 9). P. brevi-compactum was used to prepare 9-hydroxyellipticine (22) from the methoxylated precursor, and 150 mg of product was obtained from 400 mg of starting material (37% yield). The structure of the metabolite was confirmed by direct comparison with authentic 9-hydroxyellipticine (143). O-Demethylation is a common microbial metabolic transformation with 16 and many other alkaloids (143). Meunier et al. have also demonstrated that peroxidases catalyze the O-demethylation reaction with 9-methoxyellipticine (145). 

Schilling, R., G. Engelhardt, and P.R. Wallnofer (1985). Degradation of the herbicide metribuzin (Sencor) by pure cultures of Cunninghamella echinulata Thaxter ATCC 38447. Chemosphere, 14 267-270. 

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