Cumulative Subject phosphates

Cumulative The first common step enzyme is inhibited indepently (residual activity, Ai) by each of the end products at saturation cone. The simultaneous presence of the saturation cone, of two or more end products results in the ultimate inhibition such that the total residual activity, A, = HAi. Glutamine synthetase is subject to cumulative feedback inhibition by the end products, carbamyl phosphate, Trp, AMP and CTP. 

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