Cumulative Subject iodination

Among the subjects with positive TPO antibody and normal thyrotropin at baseline, the 5-year cumulative incidence of hypothyroidism was 6.5 and 9.8 times in MAI and El compared with that in MDI. Among the subjects with positive thyroglobufin antibody and normal thyrotropin at basehne, the five-year cumulative incidence of hypothyroidism was 4.3 and 10.3 times in MAI and El, compared with that in MDI (Figure 125.2). Reinhardt et al. (1998) reported that after supplementing iodine at 250 j,g/ day to patients with Hashimotos thyroiditis (MUI, from 70p,g/g of creatinine, rose to 268p,g/g of creatinine), 20% of the patients were found to have hypothyroidism after 4 months, but only 2% of the patients with Hashimotos... 

Figure 125.2 The cumulative incidence of supranormai thyrotropin levels among subjects with euthyroidism and high levels of TPO antibody or thyrogiobuiin antibody iodine intake was mildly deficient in Panshan, more than adequate in Zhangwu, and excessive in Huanghua. The cumulative incidence increased with increasing iodine intake.

Female subjects had higher cumulative incidence than male subjects among the three cohorts. Hence, we can see that either deficient or El may cause an increase in the incidence of goiter, but for different types. In areas with deficient iodine intake, the cumulative incidence of both diffuse goiter and nodular goiter increased, but in areas with El, only the cumulative incidence of diffuse goiter increased. 

Distribution of radioiodine in two goitrous subjects (FL and DD) from a severe iodine deficient area in Zaire. 3 I thyroid content, extrathyroidal 31i pool (PB 1311 x distribution volume of thyroxine) and urine (cumulative excretion) are expressed in % of 1311 administered. Adapted from Ermans et al. (2) with the permission of the publisher... 

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See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ , ]

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