Cubebol-cubebenes sesquiterpenes

Cubebol (91), a-cubebene (92), and p-cubebene (93) are isolated Irom the berries of Piper cubeba [79]. Due to its pronounced cooling effects, cubebol was patented in 2001 as a refieshing agent for applications in various products ranging 

SCHEME 7.54 Reaction mechanism of hydroacylation cycloisomeiization of tetraenes. 

SCHEME 7.55 Cycloisomerization of polyene propargylic alcohols under gold catalysis. 

SCHEME 7.57 Key cycloisomerization reaction for the total synthesis of cubebol natural products.  

SCHEME 7.58 (a) Mechanistic pathways for cycloisomerization reaction of acetylenic esters and (b) proposed mechanism for the synthesis 

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