Crystallization of Solutes and Polymorphs

We have seen in previous sections that complex organic molecules have a tendency to form polymorphs. In addition, the solubility behavior is dependent on the counter-ion of a salt and on the solvent composition when anti-solvent is used to drive the crystallization. Changes in these variables, therefore, have the potential 

9) would significantly change the filtration rates of the crystals. There is no best method to examine the solution chemistry of a new crystallization system. However, alternative solvents and antisolvents and temperature should be examined for possible advantageous exploitation. Investigation of different solvent systems is more likely to lead to crystallization of more of the system s possible crystal forms. 

---