Crystallization of Organic Moieties

Most batch crystallization processes developed involve the crystallization of organic moieties, and, in most cases, the crystallization is from the reaction broth. This 

Organic molecules are prone to the formation of polymorphs and solvates (for details see Chapter 5). The main reason for this behavior is the large number of degrees of freedom within these molecules that allow the molecule to adopt a large variety of conformations and hence a large number of potential structures in a crystal lattice with or without solvent incorporation. Each of these new forms has a different crystal lattice and therefore most likely different lattice energy and solubility. Most important for the development of the crystallization process, each modification will have a different crystallization behavior. 

Organic molecules usually are much more sensitive toward reactions with solvents or degradation with temperature compared to inorganic materials. Each new salt that an organic base or acid is forming can be treated as a new chemical 

---