Crystal structures steroids

PXR), the Ah receptor (AhR) and the constitutive androstane receptor (CAR) ligand binding domains from the human oestrogen receptor alpha (hERalpha) crystal structure, and the human peroxisome proliferator activated receptor alpha (PPARalpha) ligand binding domain from the human PPARgamma crystal structure. / Steroid Biochem Mol Biol 2003 84 117-32. 

Gu Y, Guo J, Pal A, Pan SS, Zimniak P, Singh SV, et al. Crystal structure of human glutathione N-transferase A3-3 and mechanistic implications for its high steroid isomerase activity. Biochemistry 2004 43 15673-9. 

Barna TM, H Khan, NC Bruce, I Barsukov, NS Scrutton, PCE Moody (2001) Crystal structure of pentaeryth-ritol tetranitrate reductase flipped binding geometries for steroid substrates in different redox states of the enzyme. J Mol Biol 310 433-447. 

Per-O-acylated glycosyl iodides are stable at room temperature and can be purified on a silica gel column and stored at 0 °C. Stachulski and coworkers [202] synthesized methyl 2,3,4-tri-O-pivaloyl-glucopyranuroate iodide, which is a stable solid at 20 °C and can be stored for months at room temperature or for more than a year at 0 °C. The X-ray crystal structure of this compound, the first one of this class, shows a typical chair structure. Importantly, such a disarmed and stable iodide can be coupled with primary and secondary steroidal alcohols using I2 as a promoter, as demonstrated by the synthesis of morphine-6-glucuronide, an analgesic [202], The glycosyl donor ability... 

In an early attempt to correlate reactivity and structure Guy et al. (1977) compared the crystal structure of the steroidal ketone [56] with those of related compounds. The regioselectivity and rapid rate of the base-catalysed... 

Crystal Structures of Steroids (Duax, Weeks and Rohrer) 9 271... 

The molecule methyl-5(10)-octalin-l,6-dione (1) was chosen as model compound for the steroidal enones investigated earlier. Oriented single crystals of (1) were studied at low temperature (4 K). First the crystal structure of (1)... 

The first crystal structure of the LED of the AR in complex with metri-bolone (R1881) was solved by Matias and colleagues in 2000 [38]. The LED has a similar three-dimensional structure to the other agonist-bound steroid receptors, namely the ERa, ERj6 and the PR [38]. The fact that all steroid hormone receptors bind similar hormone response elements (HREs) stands in sharp contrast to the specific activities elicited by application of the steroid... 

Generally, the most powerful method for structural elucidation of steroids is nuclear magnetic resonance (nmr) spectroscopy. A definitive method for structural determination is x ray ciystallography. Extensive x-ray crystal structure determinations have been done on a wide variety of steroids. In addition, other analytical methods for steroid quantification or structure determination include, mass spectrometry, polarography, fhiorimeUy. radioimmunoassay, and various chromatographic techniques. 

Markovic-Housley, Z., Degano, M., Lamba, D. et al. 2003. Crystal structure of a hypoallergenic isoform of the major birch pollen allergen Bet v 1 and its likely biological function as a plant steroid carrier. J Mol Biol 325 123-133. 

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