Cryptotis parva

Least shrew, Cryptotis parva Virginia whole body 1.3-1.6 DW vs. 0.8 DW 49... 

Reddy G et al., Fourteen day toxicity evaluation of 1,3,5-trinitrobenzene (TNB) in the shrew (Cryptotis parva), Abstract, Twenty-First Meeting of the American College of Toxicology, San Diego, CA, 2000. 

FIGURE 17.1 Effects of cisplatin exposure on shrew brain contents of 2-AG and anandamide. Different groups of shrews (Cryptotis parva) were injected with varying doses of cisplatin (0, 5,10, and 20 mg/kg, i.p., n = 4 per group) and 30 min later, the animals were sacrificed by rapid decapitation, and whole brains were frozen at -80°C until endocannabinoid analysis. Significantly different from corresponding vehicle-treated control group. 

Darmani, N.A. (1998) Serotonin 5-HT3 receptor antagonists prevent cisplatin-induced emesis in Cryptotis parva a new experimental model of emesis, J. Neural Trans. 105 1143-1154. 

Darmani, N. A. and Crim, J. L. (2005) Delta-9-tetrahydrocannabinol prevents emesis more potently than enhanced locomotor activity produced by chemically diverse dopamine D2/D3 receptor agonists in the least shrew (Cryptotis parva), Pharmacol. Biochem. Behav. 80, 35-44. 

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