Cryogenically-cooled probes, natural

The incredible natural abundance double quantum transfer experiment (INADEQUATE) was proposed by Ray Freeman in 1980.1 2 The acronym of this remarkable technique sat high among the many NMR acronyms since, at the time of its birth, it accurately described all its attributes. INADEQUATE was seen as an incredible experiment with vast potential its widespread applications are dwarfed only by its inadequate sensitivity. Depending on the equipment available, an ovemight-to-weekend INADEQUATE experiment on a medium-sized molecule would typically require hundreds of milligrams of sample. Only recently have such unfavourable requirements been addressed with advent of cryogenically cooled probes. Now, INADEQUATE experiments using samples of 5-10 mg have become realistic propositions. 

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