Crosslink/Crosslinking mechanical analog

While the critical role of intrastrand 1,2-crosslinks in the mechanism of action of the anti-tumor drug cis- [PtCl2(NH3)2] is well established, much less is known about the few frans-analogs that exhibit similar efficacy. A series of 1,3-adducts has been characterized with 3-mers generally involving purine N7 coordination (32-34), and either monofunctional or interstrand adducts are formed with duplex DNA (35). However, one of the most active compounds, frans-[PtCl2 ( )-HN = C(OMe)Me 2], (2), has been shown to form a 1,2-adduct with 2-mer ribonucleotide sequence r(AG) (36). Though the formation of the... 

Bis-GMA is a well-known crosslinking monomer, which is incorporated in many dental composites and adhesives. It is added in various formulations in order to significantly increase the mechanical properties. In this context, Mou et al. undertook the synthesis of PA-6, an analog of Bis-GMA bearing two PA groups on the aromatic moieties (Scheme 8.4). ... 

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