Cross-talk between ceramide and

Cross-talk between ceramide and phospholipid biosynthesis... 

SMase activity (Mansat et al 1997) and downstream (by blocking the apoptotic effect of ceramide). However, the cross-talk between ceramides and DAG opens new intriguing avenues of research and may lead to better pharmacological maiupulation of key steps in the apoptosis/survival signaling cascade resulting in an increased chemosensitivity of neoplastic cells. 

CROSS-TALK BETWEEN DIACYLGLYCEROL AND CERAMIDE IN THE ONSET OF APOPTOSIS... 

Fig. 2 Outline of signal transduction pathways for stress kinases, JNKs, and for Map kinases, p38 and ERKl/2. Shown is the cross-talk between the various pathways. Map kinases MEKKl/2/3 activate the MAP kinases MKK4 (JNKKl) and MKK7 (JNKK2). MKK4/7 can also be activated by the Map kinases TAKl and Askl, which can also activate MKK3/6 of the p38 s pathway. Activation of Rap-GTP is capable of activating the p38 and ERKl/2 pathways. As indicated, ceramide can activate the p38 pathway, and, also, has been suggested to play a role in activation of the ERKl/2 pathway...

Several experimental findings indicate that there may be cross-talk between the sphingosine cycle and the classical diacylglycerol pathway. Cera-mide-induced apoptosis was inhibited by exposure of cells to either phospholipase C or activators of PKC (Jarvis et al., 1994). In leukemic cells, apoptosis induced by serum deprivation was associated with an increased intracellular content of both ceramide and diacylglycerol and was inhibited by exogenously added diacylglycerol (Jayadev et al.,... 

Pautz, A, Franzen, R, Dorsch, S, Boddinghaus, B, Briner, VA, Pfeilschifter, J and HuwUer, A (2002) Cross-talk between nitric oxide and superoxide determines ceramide formation and apoptosis in glomerular cells. Kidney Lnt, 61, 790-796. 

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