Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Cross-species exposure-response continuums

Defining cross-species exposure-response continuums... [Pg.66]

Accepting both Cb/U as a valid Cisf surrogate and the ability to project Cb/U accurately in large animal species, Cb/U values may be utilized to develop a mechanism-based cross-species exposure-response continuum for CNS... [Pg.66]

Figure 5 The C y-normalized cross-species exposure-response continuum for 7 across multiple pharmacology models [42]. A listed value (Cx) is the C iU (nM) affecting a response in assay X. RAM(r), rat radial arm maze DSR(nhp), nonhuman primate delayed spatial response task e-phys(r), rat electrophysiology model NOR(r), rat novel object recognition cGMP(m,r), mouse/rat cerebellar cGMP trem(nhp), nonhuman primate tremor rot(m), mouse rotarod. Figure 5 The C y-normalized cross-species exposure-response continuum for 7 across multiple pharmacology models [42]. A listed value (Cx) is the C iU (nM) affecting a response in assay X. RAM(r), rat radial arm maze DSR(nhp), nonhuman primate delayed spatial response task e-phys(r), rat electrophysiology model NOR(r), rat novel object recognition cGMP(m,r), mouse/rat cerebellar cGMP trem(nhp), nonhuman primate tremor rot(m), mouse rotarod.
See other pages where Cross-species exposure-response continuums is mentioned: [Pg.68]    [Pg.68]   


SEARCH



Cross-species

Exposure-response

© 2024 chempedia.info