Cross-References Between Chapters

In a book such as this it is impossible to avoid cross-references between chapters. However, it is equally difficult to ensure that such cross-references supply the answers expected of them. I have therefore attempted to make each chapter as free-standing as possible and have used the resulting duplications as a mechanism for deepening the discussion. This strategy can produce its own problems as well as benefits I hope that the index will provide direction to sufficient additional material to deal with the problems ... 

Unfortunately, in many medical or biomedical programmes, biochemical education has been reduced to the presentation of basic facts. It is the aim of this book to provide the link between these facts and medical practice to achieve a more complete biochemical education. Each topic is presented in one complete section or one chapter, which can be studies independently, unencumbered by extraneous material. Nonetheless, cross-references between topics are emphasised to help the student appreciate the common biochemical principles underlying health and disease. 

The first chapter concerns the chemistry of the oxidation catalysts, some 250 of these, arranged in decreasing order of the metal oxidation state (VIII) to (0). Preparations, structural and spectroscopic characteristics are briefly described, followed by a summary of their catalytic oxidation properties for organic substrates, with a brief appendix on practical matters with four important oxidants. The subsequent four chapters concentrate on oxidations of specific organic groups, first for alcohols, then alkenes, arenes, alkynes, alkanes, amines and other substrates with hetero atoms. Frequent cross-references between the five chapters are provided. 

This chapter serves three purposes (a) to provide a brief overview of PBPK modeling, (b) to present a tutorial on the issues and steps involved in the development of a PBPK model, and (c) to present an application and discuss relevant issues associated with model refinement, evaluation, parameter estimation, and sensitiv-ity/uncertainty analysis. First, some basic background information is provided, and references to important resources are presented. Then the process of developing a PBPK model is discussed, and a step-by-step description of a PBPK modeling example is provided, along with a brief discussion on relevant complementary issues such as model parameter estimation and sensitivity/uncertainty analysis. The example is presented in a manner that a novice PBPK modeler can follow the model structure, mathematical equations, and the code. Relevant cross-references between the equations, parameter tables, and the actual code is presented. Though the example is implemented in Matlab (5), it does not require substantial Matlab... 

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