Cross-Reactions Between Neuromuscular Blocking Drugs

4 Cross-Reactions Between Neuromuscular Blocking Drugs 

Both skin and IgE antibody tests can be used to detect allergenic cross-reactivity between NMBDs but the frequency of cross-reactions is generally higher when determined by interaction 

Patient s Drug or analog Amount (nmol/tube) of NMBD to produce 50 % inhibition of uptake of anti-human IgE  

From Baldo BA et al. On the origin and specificity of antibodies to neuromuscular blocking (muscle relaxant) drugs an immunochemical perspective. Clin Exp Allergy 2009 39 325). Reprinted with permission from John Wiley and Sons. 

Competitive NMBDs-bulky, rigid molecules Alcuronium 

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