Cross-Linking with Divinylsulfone

The stable hydrogels of HA can be obtained by cross-linking of HA with divinylsulfone. 

In alkaline media divinylsulfone or butadienesulfone, sulfonyl ether linkage is formed between hydroxyl groups of HA. Depending on the reaction conditions, the reaction products could have different consistencies from the soft gels up to solid films (the same method could be used for formation the membranes and hollow pipe). Such products, used as microimplants, are allowed to stay in the body for a long time, especially in the places where implants are not affected by mechanical forces. 

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