Critical Statement on Peptide Synthesizers

The third method for automatic monitoring of the gel phase synthesis has long been known [ 196] - the perchloric acid titration on polymer — and recently was built into a computer-controlled peptide synthesizer [134]. Here, the results of the analytical determinations are fed back into the monitor system, which is programmed to optimize the course of the synthesis based on the titration data. This example of best realized automatization to date, however, is restricted to acid-tolerant synthesis strategies. The limiting chemical conditions of the analytical principle in use were already discussed on p. 43—44. 

With most care, one has to look at possible corrosion on electromechanical parts like relays, multifunctional switches and on solenoid valves. In the latter relation one has to warn of a prevalent misunderstanding Polytetrafluoroethylene, though very inert against 

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