Critical care drug-induced

Schetz, M. et al., Drug-induced acute kidney injury, Cure Opin. Critical Care, 11, 555,... 

At Alfama, the medical indication chosen was the treatment (rescue) of acute liver failure induced by acetaminophen (Tylenol , paracetamol), where the activity of CO gas had already been demonstrated in animal models (Fig. 41.7) [51]. The treatment is restricted to the critical care room where injectable drugs are preferred [122]. The goal was to obtain a CORM providing total liver rescue within a wide time window, enabling later onset of treatment after intoxication challenge, thus outperforming the present treatment with A-acetylcysteine. 

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