Coupling Tishchenko reaction

The coupling of two molecules of aldehydes into esters (Tishchenko reaction) has been used as an efficient method for the industrial preparation of dimeric esters. Although a number of systems for such reactions using transition-metal catalysts have been reported [73], there is stiU great room for improvement of the synthetic efficiency. 

Tishchenko reaction. Aromatic aldehydes undergo redox coupling to give benzyl aroates in THF. In some cases the yield can be as high as 99%. 

Redox coupling and addition. The Tishchenko reaction products of aldehydes, which are formed by the action of the organosamarium species, are trapped by vinyl esters in situ. For the Tishchenko reaction, (Cp >2LaCH(TMS)2 is also effective. ... 

Other modifications of the Tishchenko reaction are also known, and catalytic cascade reactions are particularly interesting. Examples include combinations oflish-chenko with aldol reactions in the presence of achiral [169] and chiral catalysts [170], Tishchenko/esterification sequences [171], tandem semipinacol rearrangement/Tish-chenko reactions [172] and couplings of vinyl esters with aldehydes [173]. 

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