Coupling of Microwave Radiation with Solvent Free Heterocyclic Synthesis

5 Coupling of Microwave Radiation with Solvent Free Heterocyclic Synthesis 

Avoiding the use of organic solvents during MAOS of heterocycles lead to a clean, efficient and economical technology (Green Chemistry). Apart from this the safety is increased, workup is considerably simplified, cost is reduced, the use of toxic solvents can be avoided and the reactivities and sometimes the selectivities can also be enhanced without dilution. Due to these positive aspects of solvent free synthesis, there is a marked increase in the use of environmentally benign reagents and procedures. 

The three types of solvent free procedures that can be coupled with microwave activation can be listed as  

---