Cotlove model

The second level used to define the requirement for analytical quality is often cited as the Cotlove model [2], defining acceptable analytical imprecision as less than 0.5 times the within-subject biological variation measured as the coefficient of variation... 

Gold H, Catell McK, Greiner T, Hanlon LW, Kwit NT, Modell W, Cotlove E, Benton J, Otto HL. Clinical pharmacology of digoxin. J Pharmacol Exp Ther 1953 109 45-57. 

The collected effluent was analyzed for C1, A, A-S0, and A-S02. Chloride was determined using a Buchler-Cotlove chlorido-meter. Aldicarb, A-SO and A-S02 were extracted with methylene chloride and analyzed using a Hewlett-Packard model 5880A gas chromatograph with a nitrogen-phosphorus detector and a fused silica capillary column coated with methyl silicone. Further details of the aldicarb analytical techniques are reported elsewhere (6). 

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