Cosolvents intramuscular injection

Brazeau, G.A. Fung, H-F. Physicochemical properties of binary organic cosolvent-water mixtures and their relationships to muscle damage foUowing intramuscular injection. J. Parent. Sci. Technol. 1989, 43 (4), 144—149. 

Brazeau, G.A. Fung, H-L. Use of an in vitro model for the assessment of muscle damage from intramuscular injections in vitro-in vivo correlation and predictability with mixed cosolvent systems. Pharm. Res. 1989, 6 (9), 766-771. 

Hazardous Decomp. Prods. Heated to decomp., emits acrid smoke and irritating vapors Uses Surfactant, emulsifier for foods, cosmetics, pharmaceuticals, household prods., industrial applies., polymerization, pulp/paper, metalworking, lubricants, textiles, agric., paints, adhesives emulsifier in food pkg. oil additive corrosion inhibitor cosolvent stabilizer for foods antimicrobial in cane and beet sugar mills Regulatory FDA 21CFR 175.320, 178.3400 Europe listed UK approved FDA approved for intramuscular injectables NF, BP, EP compliance Manuf./Distrib. ASiE Connock http //www.connock.co.uk, Aldrich http //www.sigma-aldrich. com. Ash land... 

Considerable interest exists in the local effects that cosolvents exert during IV and intramuscular (IM) injection. Several investigations have studied the... 

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