Cortisone tetrahydro

Turpeinen, U. Markkanen, H. Sane, T. Hamalainen, E. Determination of free tetrahydrocortisol and tetrahydro-cortisone ratio in urine by liquid chromatography-tandem mass spectrometry. Scand. J. Clin. Lab. Invest. 2006, 66 (2), 147-159. 

Determination of Urinary Tetrahydro-cortisone, Tetrahydrocortisol, and 3a-Allotetrahydrocortisol by Gas Chromatography Steroids 6(5) 583-596 (1965) CA 64 2353b... 

This is a collective term for a group of corticosteroids which includes cortisol, cortisone, 11-deoxycortisol and their tetrahydro derivatives which are measured in plasma and urine by the Porter-Silber reaction. The term 17-hydroxysteroids is often used synonymously with 17-oxogenic steroids and to most intents and purposes they mean the same. However there is a subtle difference between the two in that 17-oxogenic steroids (determined by the Zimmermann reaction after reduction and oxidation) measures, in addition to the compounds mentioned above, cortol and cortolone. 

The reaction of certain corticosteroids with phenylhydrazine in the presence of alcohol and sulphuric acid to give a yellow colour. Steroids which give this reaction have a dihydroxy-acetone side chain and they include such compounds as cortisol, 11-deoxycortisol, cortisone and their tetrahydro derivatives. Collectively they are known as 17-hydroxycorticosteroids (qv) or Porter-Silber chromogens. 

Glowka, F. K. Kosicka, K. Karazniewicz-Lada, M. HPLC method for determination of fluorescence derivatives of cortisol, cortisone and their tetrahydro-and allo-tetrahydro-metabolites in biological fluids. J. Chromatogr., B 2010, 878, 283-289. 

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