Corticotropin zinc complexes

Coproporphyrin I synthesis, 816 Coronands classification, 919 metal ion complexes, 928,938 Corphins, 855 Coninoids, 983 Corrins, 871-888 demetallation, 882 deuteration, 879 electrophilic reactions, 879 metallation, 882 NMR, 878 nucleophilicity, 886 nucleophilic reactions, 879 oxidation, 879 oxidative lactamization, 880 oxidative lactonization, 880 photochemistry, 887 reactions, 879 at metal, 885 rearrangements, 879 redox chemistry, 888 spectra, 877 synthesis, 878 Corroles, 871-888 demetallation, 874 deuteration, 872 hydrogenation, 872 metallation, 874 reactions, 872 at metal, 875 redox chemistry, 876 synthesis, 871 Corticotropin zinc complexes medical use, 966 Cotton effect anils, 717... 

The biologic half-lives of ACTHi 39 and ACTHi 24 are under 20 minutes. Tissue uptake occurs in the liver and kidneys. ACTHi 39 is transformed into a biologically inactive substance, probably by modification of a side chain. ACTH is not excreted in the urine in significant amounts. The effects of long-acting repository forms of porcine corticotropin persist for up to 18 hours with a gelatin complex of the peptide and up to several days with a zinc hydroxide complex. 

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