Corticium caeruleum

The leuco peracetate of thelephoric acid (85) has been isolated from Boletopsis leucomelaena [69], The leuco permethyl ether of thelephoric acid (86) was obtained in minute amounts from mycelial mat of Pulcherricium caeruleum (Corticium caeruleum), a basidiomycete characterized by an indigo blue colour of its hymenial surface, and its... 

Thelephoric add (7.21) is a further oxidation product that is widespread amongst the Basidiomycetes. The delocalization of the phenolate anions forms the basis of the colour reactions that are observed when the fruiting bodies come into contact with alkali. The quinhydrones of corticins A (7.22) and B and their quinones give rise to the blue colour of Corticium caeruleum. The terphenylquinols are powerful anti-oxidants. 

Scheme 7. Five phytoalexins, lacinilene C [1], lacinilene C 7-methyl ether [2], scopoletin [3], 2-hydroxy-7-methoxycadalene [4], and 2,7 dihydroxycadalene [5]) induced by A. flavus in cotton leaves. The antibiotic cortalcerone [6] is induced in the fungus Corticium caeruleum by various stimuli.

Agar cultures of the fungus Corticium caeruleum will only express the antibacterial cortalcerone (6, scheme 7) after activating treatment with toxic vapors or when being subjected to supraoptimal temperatures (136). 

Recently, the leuco-peracetate (54) of thelephoric acid has been isolated from sporophores of Boletopsis leucomelaena (386). The leuco-permethyl ether (67) of thelephoric acid occurs in minute amounts in the indigo blue coloured mycelial mats of Pulcherricium caeruleum ( = Corticium caeruleum) and its structure has been established by an X-ray crystal analysis (581, 711). The chemical nature of the blue pigment from this organism is a matter of dispute. Briggs et al. (135) obtained blue solutions (A, ax = extraction of the mycelium... 

Neveu, a., R. Baute, G. Bourgeois, and G. Deffieux Recherches sur le Pigment Bleu du Champignon Corticium caeruleum (Schrad. ex Fr.) Fr. (Aphyllophorales) II. Relations Structurales avec Certains Derives de I Acide Thelephorique Etude par Spectrometrie de Masse. Bull. soc. pharm. Bordeaux 113, 121 (1974). 

Weisgraber, K., U. Weiss, G.W.A. Milne, and J.V. Silverton Hexamethyl Ether of Leuco-Thelephoric Acid from Corticium caeruleum. Phytochem. 11, 2585 (1972). 

Isol. from Corticium caeruleum. Shows antibiotic props. Sol. H2O. 

The antibiotic cortalcerone 42, a metabolite of the fungus corticium caeruleum, has been prepared from D-glucose using a pyranose 2-oxidase and an aldos-2-ulose dehydratase to prepare the unstable tricarbonyl derivative 41 and hence the product, as shown in Scheme 1. ... 

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