Core-multishell architectures

FIGURE 1.2 Supramolecular aggregate formation and drug encapsulation of dendritic core-multishell architectures (left) and cryo-TEM structure elucidation of the formed drug complexes (right). Source Radowski et al. [1], figure 4. Reproduced with permission from John Wiley Sons. 

Core-multishell architectures (CMS) have been developed based on hyper-branched polymers, such as poly(ethylene imine) (PEI) and PG with an amphiphilic alkyl-PEG shell. These CMS nanocarriers can encapsulate a wide range of hydrophobic and hydrophilic substances that can be transported in both organic solvents and aqueous systems [36, 37] (Eig. 6.15). 

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