Core challenges

Bate and colleagues suggest that the healthcare systems they studied face six core challenges - the basic human problems of the formulation above. These are ... 

Finding good electrocatalysts is therefore one of the core challenges in solar fuel production. 

The analyses of system failures which could challenge the containment or lead to the release of radioactivity form the licensing process. The design basis analyses are deterministic, and degraded core accidents are not considered. PSA determines the probabilities of the numerous sequences that could lead to core degradation and how the core behaves. 

Pressure-tubes allow the separate, low-pressure, heavy-water moderator to act as a backup hesit sink even if there is no water in the fuel channels. Should this fail, the calandria shell ilsdf can contain the debris, with the decay heat being transferred to the water-filled shield tank around the core. Should the severe core damage sequence progress further, the shield tank and the concrete reactor vault significantly delay the challenge to containment. Furthermore, should core melt lead to containment overpressure, the concrete containment wall will leak and reduce the possibility of catastrophic structural failure (Snell, 1990). 

The Global Harmonisation Task Force (GHTF) was conceived in 1992 to address similar issues for medical devices. It has a broader regional base than its pharmaceutical counterparts in that it includes representatives from Canada and Australia in its core group, in addition to those from the EU, US and Japan. In some ways, it also faces a stiffer challenge in that there is more divergence in the regulatory... 

Light wave technologies provide a number of special challenges for polymeric materials. Polymer fibers offer the best potential for optical communications in local area network (LAN) applications, because their large core size makes it relatively cheap to attach connectors to them. There is a need for polymer fibers that have low losses and that can transmit the bandwidths needed for LAN applications the aciylate and methacrylate polymers now under study have poor loss and bandwidth performance. Research on monomer purification, polymerization to precise molecular-size distributions, and weU-controlled drawing processes is relevant here. There is also a need for precision plastic molding processes for mass prodnction of optical fiber connectors and splice hardware. A tenfold reduction in the cost of fiber and related devices is necessaiy to make the utilization of optical fiber and related devices economical for local area networks and tlie telecommunications loop. 

The synthesis of a compound with a [Fe3S4l core analogous to that found in proteins proved to be a challenging task that was finally accomplished by Zhou and Holm in 1995 (49). This was the result of an extensive research program initiated by the Holm group soon after the discovery of biological 3Fe centers in 1980. A brief overview of the different stages of this work is presented next. 

Our latest efforts have been to concentrate on investigating the architecture of the DIB core. As discussed before, the average number of branches per molecule (B) determined by selective link destmction and equilibrium swelling showed good agreement with the kinetic B (Equation 7.2). However, branching analysis by SEC proved to be a challenge. 

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