Core-Box Modeling in the Biosimulation of Drug Action

Biosimulation has the potential to drastically improve future drug development mathematical models may be used to obtain maximal information from experimental data, and can be used to pin-point potential drug targets, in a much more systematic manner than is the case today. 

However, for this potential to be fulfilled, the developed models must themselves fulfill a number of requirements. For instance, the models must be trustworthy, and contain the necessary degree of mechanistic details. These two requirements are difficult to fulfill simultaneously, since a mechanistically detailed model typically becomes unidentifiable (i.e., over-parametrized with respect to existing data), which means that the model predictions are the result of arbitrary choices on a parameter manifold, and thus much less trustworthy. 

Biosimulation in Drug Development. Edited by Martin Bertau, Erik Mosekilde, and Hans V. Westerhoff Copyright 2008 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim ISBN 978-3-527-31699-1 

---

Core-Box Modeling in the Biosimulation of Drug Action 5.2.4.2 Model Quality Analysis... 

---