Copper transport agent

Crider, S.E., Holbrook, R.J., Franz, K.J. Coordination of platinum therapeutic agents to met-rich motifs of human copper transport protein. Metallomics 2, 74—83 (2010)... 

In another rare inherited disorder, called Wilson s disease, excessive amounts of copper accumulate in liver and brain tissue. A prominent symptom of the disease is the deposition of copper in greenish-brown layers surrounding the cornea, called Kayser-Fleischer rings. Wilson s disease is now known to be caused by a defective ATP-dependent protein that transports copper across cell membranes. Apparently, the copper transport protein is required to incorporate copper into ceruloplasmin and to excrete excess copper. In addition to a low copper diet, Wilson s disease is treated with zinc sulfate and the chelating agent penicillamine (p. 123). Describe how these treatments work. (Hint Metallothionein has a greater affinity for copper than for zinc.)... 

Fig. 44. Schematic examples of facUitated transport of gases and metal ions. The gas-transport example shows the transport of oxygen across a membrane using hemoglobin (HEM) as the carrier agent. The ion-transport example shows the transport of copper ions across the membrane using a Uquid...

Chemical Reactivity - Reactivity with Water No reaction Reactivity with Common Materials Data not available Stability During Transport Stable Neutralizing Agents for Acids and Caustics Not pertinent Polymerization May occur at temperature above 50°C (120° F) Inhibitor of Polymerization Oxygen (air) plus 50 ppm of copper as copper sulfate. 

Chemical Reactivity - Reactivity with Water No reaction Reactivity with Common Materials Attacks copper and copper alloys these metals should not be used. Penetrates leather, so contaminated leather shoes and gloves should be destroyed. Attacks aluminum in high concentrations Stability During Transport Stable Neutralizing Agents for Acids and Caustics Not pertinent Polymerization May occur spontaneously in absence of oxygen or on exposure to visible light or excessive heat, violently in the presence of alkali. Pure ACN is subject to polymerization with rapid pressure development. The commercial product is inhibited and not subject to this reaction Inhibitor of Polymerization Methylhydroquinone (35 - 45 ppm). 

---