Copper-mediated Addition and Substitution Reactions of Extended Multiple Bond Systems

Copper-mediated Addition and Substitution Reactions of Extended Multiple Bond Systems 

As far as substrates are concerned, while the usual 1,4-addition and 1,3-substi-tution (Sn2 ) reactions of simple unsaturated substrates have so far predominated, analogous transformations of ambident substrates with extended multiple bond systems (i.e., with two or more reactive positions) have come to attention only recently. Here, systematic investigations have shown that such 1,5-substitutions and even 1,6- and 1,8-addition reactions proceed highly regioselectively and ste-reoselectively, in particular when the substrate contains at least one triple bond besides one or more conjugated double bonds. These unusual reaction types not 

Copper-mediated Addition Reactions to Extended Michael Acceptors 

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Krause, N. Hoffmann-Roder, A. Copper-mediated Addition and Substitution Reactions of Extended Multiple Bond Systems. In Modem Organocopper Chemistry, Krause, N., Ed. Wiley-VCH Weinheim, 2002 pp 145-166. 

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