COPPER-CATALYZED CONJUGATE ADDITION OF ORGANOZINC

COPPER-CATALYZED CONJUGATE ADDITION OF ORGANOZINC REAGENTS TO a.p-UNSATURATED KETONES, 76, 252... 

Copper-Catalyzed Conjugate Addition of Functionalized Organozinc Reagents to a,p-Unsaturated Ketones Preparation of Ethyl 5-(3-Oxocyclohexyljpentanoate. 

COPPER-CATALYZED CONJUGATE ADDITION OF FUNCTIONALIZED ORGANOZINC REAGENTS TO a,p-UNSATURATED KETONES ETHYL 5-(3-OXOCYCLOHEXYL)PENTANOATE (Pentanoic acid, 5-(3-oxocyclohexyl)-, ethyl ester)... 

Organozinc Cuprate to Nitroolefins. The copper-catalyzed conjugate addition of functionalized diorganozinc cuprates to nitroolefins leads to synthetically versatile nitro compounds in good yields (eq 18). ... 

There are a large number of reports on copper(I)-catalyzed conjugate additions, yet there is only scant information available about their reaction mechanisms. Recently, the conjugate addition of organozinc compounds to enones was found by Kitamura, Noyori, et al. to be catalyzed by N-benzylbenzenesulfonamide and CuCN, and the mechanism was scrutinized (Fig. 10.1). The kinetic rate was found to be first order in the concentrations of the catalyst that exist in equilibrium with R2Zn and enone [77]. 

The copper-catalyzed conjugate addition reaction of organozinc reagents has reached a prominent level of success by the development of sophisticated chiral phosphorus ligands. Nickel catalysts have also been surveyed by several groups. 

Copper-catalyzed Enantioselective Conjugate Addition Reactions of Organozinc Reagents... 

Feringa, B. L. Naasz, R. Imbos, R. Arnold, L. A. Copper-catalyzed Enantioselective Conjugate Addition Reactions of Organozinc Reagents. In Modem Organocopper Chemistry Krause, N. Ed. Wiley-VCH GmbH Weinheim, 2002 Chapter 7, pp 224—258. 

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